beta Pix-b(L), a novel isoform of beta Pix, is generated by alternative translation
- Authors
- Rhee, Sangmyung; Yang, Soo Jung; Lee, Seung Joon; Park, Dongeun
- Issue Date
- May-2004
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- beta Pix; calponin homology; internal ribosome entry site; alternative translation
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.318, no.2, pp 415 - 421
- Pages
- 7
- Journal Title
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Volume
- 318
- Number
- 2
- Start Page
- 415
- End Page
- 421
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/57715
- DOI
- 10.1016/j.bbrc.2004.04.039
- ISSN
- 0006-291X
1090-2104
- Abstract
- betaPix (Pak-interacting exchange factor) isoforms are recently identified guanine nucleotide exchnge factors (GEFs) for Rho family GTPases. Rac/Cdc42, that are key players in the regulation of actin dynamics. Here we show that a novel 105-kDa betaPix isoform, betaPix-b(L), is generated by alternative translation of betaPix-b mRNA. Translation of betaPix-b(L) starts at an atypical initiation site, GTG, that is located 57 nucleotides downstream from the newly identified 5' end of betaPix-b cDNA. The expression of two isoforms, betaPix-b and betaPix-b(L). from betaPix-b mRNA is controlled by an internal ribosome entry site (IRES)-driven mechanisin. Comparing to betaPix-b, betaPix-b(L) Contains additional 105 amino acids composed of a calponin homology (CH) domain and a serine-rich sequence in the N-terminus. The expression of betaPix-b(L) in rat brain is developmentally regulated and high in the embryonic stages, suggesting that the function of betaPix-b(L) is more heavily required during the early stages of brain development. (C) 2004 Elsevier Inc. All rights reserved.
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