Sphingosine Analog AAL- R Promotes Activation of LCMV-Infected Dendritic Cellsopen access
- Authors
- Seo, Young-Jin; Hahm, Bumsuk
- Issue Date
- Mar-2014
- Publisher
- MARY ANN LIEBERT, INC
- Citation
- VIRAL IMMUNOLOGY, v.27, no.2, pp 82 - 86
- Pages
- 5
- Journal Title
- VIRAL IMMUNOLOGY
- Volume
- 27
- Number
- 2
- Start Page
- 82
- End Page
- 86
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/57759
- DOI
- 10.1089/vim.2013.0096
- ISSN
- 0882-8245
1557-8976
- Abstract
- Sphingosine analogs display diverse immunoregulatory activities with curative potential in autoimmune diseases and viral infections. Recently, the sphingosine analog AAL-R was shown to increase DC activation upon TLR7 stimulation. Here, we investigated the effect of AAL-R on activation of dendritic cells (DCs) infected by lymphocytic choriomeningitis virus (LCMV). Concomitant treatment of LCMV-infected DCs with AAL-R enhanced DC maturation and DC ability to stimulate and expand antiviral CD8(+) T cells. Importantly, AAL-R's stimulatory activity was abrogated in type I interferon (IFN) receptor-deficient DCs following LCMV infection. In support of this observation, AAL-R increased type I IFN production from DCs infected with LCMV. Taken together, the sphingosine analog could directly act on DCs to promote defensive host DC responses to the viral invasion via type I IFN signaling.
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Collections - College of Natural Sciences > Department of Life Science > 1. Journal Articles
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