High Transcript Level of FLT3 Associated with High Risk of Relapse in Pediatric Acute Myeloid Leukemiaopen access
- Authors
- Kang, Hyoung Jin; Lee, Ji Won; Kho, Sang Hyeok; Kim, Min Jeong; Seo,Young Jin; Kim, Hyery; Shin, Hee Young; Ahn, Hyo Seop
- Issue Date
- Jun-2010
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- FLT3; Transcript Level; Leukemia, Myeloid, Acute; Pediatric Age
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.25, no.6, pp 841 - 845
- Pages
- 5
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 25
- Number
- 6
- Start Page
- 841
- End Page
- 845
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/57765
- DOI
- 10.3346/jkms.2010.25.6.841
- ISSN
- 1011-8934
1598-6357
- Abstract
- Identification of prognostic factors and risk-based post-remission therapy was proposed to improve the outcomes of acute myeloid leukemia (AML) and a mutation of FLT3 has been reported to be a risk factor, especially for pediatric patients. Recently, FLT3 expression level was implicated to have prognostic significance in adults, but little is known for childhood AML. To define the prognostic significance, transcript level of FLT3 was analyzed in 52 pediatric AML patients. The median copy number of FLT3 was 4.6 x 10(3) (40-5.9 x 10(7) copies)/1.0 x 10(6) GAPDH copy, and the relapse free survival of patients with high transcript level of FLT3 (>10(6) copy number) (0%) was significantly lower than that of the others (53.2%). High transcript level of FLT3 was associated with a markedly high risk of relapse. The development of new therapeutic scheme such as a frontline allogeneic stem cell transplantation or administration of FLT3 inhibitor is needed to improve outcomes.
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