Swelling behavior of gamma-irradiation cross-linked elastomeric polypentapeptide-based hydrogels
- Authors
- Lee, Jonghwi; Macosko, Christopher W.; Urry, Dan W.
- Issue Date
- Jun-2001
- Publisher
- AMER CHEMICAL SOC
- Citation
- MACROMOLECULES, v.34, no.12, pp 4114 - 4123
- Pages
- 10
- Journal Title
- MACROMOLECULES
- Volume
- 34
- Number
- 12
- Start Page
- 4114
- End Page
- 4123
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/57960
- DOI
- 10.1021/ma0015673
- ISSN
- 0024-9297
1520-5835
- Abstract
- The dynamic and equilibrium swelling behavior are reported for four gamma -irradiation crosslinked elastic protein-based polymers comprised of repeating pentapeptide sequences. The elastomeric polypentapeptides, previously prepared using recombinant DNA technology, are (GVGVP)(251), (GVGIP)(260), (GVGVP GVGVP GEGVP GVGVP GVGVP GVGVP)(35)](GVGVP), and (GVGVP GVGTFP GEGFP GVGVP GVGFP GFGFP)(35)](GVGVP), where G = glycine, V = valine, P = proline, I = isoleucine, F = phenyalanine, and E = glutamic acid. These polymers had been gamma -irradiation cross-linked into elastic matrices using doses ranging from 6 to 34 Mrad. Fick's law was able to explain their initial dynamic swelling behavior. Thermal history was found to be a variable affecting dynamic swelling, The equilibrium swelling ratio was dependent on both temperature and pH (for the E-containing polymers) and analyzed using the Flory-Huggins interaction parameter. The interaction parameter could be related with the T-t mechanism developed for polypeptides. Different continuities found in the phase transitions of these polymers and poly(N-isopropylacrylamide) were discussed in terms of cooperative units.
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Collections - College of Engineering > School of Chemical Engineering and Material Science > 1. Journal Articles
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