In vitro Therapeutic Effects of Folate Receptor-Targeted Delivery of Anti-Atherogenic Nanodrug on Macrophage Foam Cells
- Authors
- Song, Y.J.; Jung, S.Y.; Park, Kyeong Soon
- Issue Date
- Oct-2022
- Publisher
- Polymer Society of Korea
- Keywords
- folate receptor; lipid droplet; lobeglitazone; macrophage foam cells; nanodrug
- Citation
- Macromolecular Research, v.30, no.10, pp 703 - 706
- Pages
- 4
- Journal Title
- Macromolecular Research
- Volume
- 30
- Number
- 10
- Start Page
- 703
- End Page
- 706
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/58526
- DOI
- 10.1007/s13233-022-0082-0
- ISSN
- 1598-5032
2092-7673
- Abstract
- Folate receptors (FRs) are overexpressed on activated macrophages in inflammatory diseases. In this regard, the FRs-targeting strategy is a good option for the diagnosis and treatment of macrophage-mediated diseases. Here, we developed FRs-targeted nanomaterials that specifically deliver the anti-atherogenic drug lobeglitazone into macrophage foam cells via a strong binding affinity to FRs. The prepared FRs-targetable nanodrug is nontoxic to macrophage foam cells and efficiently delivers lobeglitazone into macrophage foam cells via the FRs-mediated endocytosis. Consequently, the FRs-targetable nanodrug significantly decreases the formation of foam cells by inhibiting the accumulation of lipid droplets in macrophage foam cells. © 2022, The Polymer Society of Korea and Springer.
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Collections - College of Biotechnology & Natural Resource > Department of Systems Biotechnology > 1. Journal Articles
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