PTPase의 작용에 menadione이 미치는 활성 기작Mechanism of Menadione on the Action of PTPase
- Authors
- Ham, Seung Wook; Park, Hee-Joong; Lim, Doo-Hyeon
- Issue Date
- Dec-1995
- Publisher
- 중앙대학교 기초과학연구소
- Citation
- 기초과학연구소 논문집, v.9, pp 87 - 92
- Pages
- 6
- Journal Title
- 기초과학연구소 논문집
- Volume
- 9
- Start Page
- 87
- End Page
- 92
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/58529
- Abstract
- Vitamin K3(menadione) has been shown to exhibit a broad range of antitumor activity in human cells as well as a phosphatase cofactor. It also imposed lower level of toxicity than other cancer chemotherapeutic drugs of quinone structure. Juan and Wu have recently demeonstrated that the action of menadione is dose-dependent and cell cycle-specific. In this study, we have examined the effect of menadione in the action of cdc25 PTPase which is important of the control of cell cycle progression by the signal transduction pathway. Our mechanistic analysis with the model reaction has led to a new interpretation of the role of menadione. We also investigated that thiolate addition of cdc25 PTPase to menadione leads to directly to irreversible inhibition by covalent modification.
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Collections - College of Natural Sciences > Department of Chemistry > 1. Journal Articles
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