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Facile preparation of poly(N-isopropylacrylamide)/graphene oxide nanocomposites for chemo-photothermal therapyopen access
- Authors
- Baipaywad, Phornsawat; Ryu, Naeun; Im, Soo-Seok; Lee, Ukjae; Son, Hyung Bin; Kim, Won Jong; Park, Hansoo
- Issue Date
- Dec-2022
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Poly(N-isopropylacrylamide); graphene oxide; nanogel; chemotherapy; photothermal therapy
- Citation
- DESIGNED MONOMERS AND POLYMERS, v.25, no.1, pp 245 - 253
- Pages
- 9
- Journal Title
- DESIGNED MONOMERS AND POLYMERS
- Volume
- 25
- Number
- 1
- Start Page
- 245
- End Page
- 253
- ISSN
- 1385-772X
1568-5551
- Abstract
- Carbon-based nanomaterials, such as carbon nanotubes, fullerenes, nanodiamonds, and graphene, have been investigated for various biomedical applications, including biological imaging, photothermal therapy, drug/gene delivery, cancer therapy, biosensors, and electrochemical sensors. Graphene oxide (GO) has unique physicochemical properties and can be used to restore conductivity through oxidation. In this study, we developed poly(N-isopropylacrylamide) (PNIPAM)-based nanogel systems containing GO for controlled in vitro drug delivery. The photothermal effects of the PNIPAM/GO- and PNIPAMAAM/GO-based nanogel systems were enhanced. The release of DOX from the PNIPAM/GO-based nanogel was achieved using the photothermal effect of near-infrared irradiation. Using a Cell Counting Kit-8 assay, the cytotoxicity of all conditions demonstrated that the PNIPAM composite-based nanogels were biocompatible with no significance.
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