Genetic Variations of Eight Candidate Genes in Korean Obese Group
- Authors
- Kang, Byung Yong; Lee, Kang Oh; Bae, Joon Seol; Kim, Ki Tae; Yoon, Moon-Young; Lim, Seok Rhin; Seo, Sang Beom; Shin, Jung Hee; Lee, Chung Choo
- Issue Date
- Mar-2002
- Publisher
- 한국환경성돌연변이발암원학회
- Keywords
- candidate genes; obesity and polymorphism
- Citation
- 한국환경성돌연변이발암원학회지, v.22, no.1, pp 39 - 46
- Pages
- 8
- Journal Title
- 한국환경성돌연변이발암원학회지
- Volume
- 22
- Number
- 1
- Start Page
- 39
- End Page
- 46
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/58925
- ISSN
- 1225-6307
- Abstract
- Obesity is a complex metabolic disorder with a strong genetic component. There are many candidate genes for obesity and its related phenotypes. We studied genetic variations between Korean obese and lean groups. Polymorphisms investigated were the Msp I polymorphism of the
α2A-adrenergic receptor (α2A-AR) gene, the Mnl I polymorphism of the α2-adrenergic receptor (α2-AR) gene, the BstO I polymorphism of the β3-adrenergic receptor (β3-AR) gene, the Pml I polymorphism of the lamin A/C (LMNA) gene, the Hga I polymorphism of the clearance receptor (NPRC) gene, the Msp I polymorphism of the leptin gene, BclI polymorphism of the uncoupling protein 1 (UCPI) gene and the Hha I polymorphism of the fatty acid binding protein 2 (FABP2) gene. Among these genetic markers, Pml I polymorphism at the LMNA gene and Bcl I polymorphism at the UCP1 gene were significantly associated with obesity. However, further studies are required whether thease findings are reproduced in large population, although two polymorphisms might be useful as genetic markers in the ethiology of obesity in Korean population.ion.
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