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Histone Acetyltransferases p300CBP in Transcriptional Regulation히스톤 아세틸화효소 p300/CBP 의 전사조절역할
- Authors
- Seo, Sang-Beom
- Issue Date
- Sep-2004
- Publisher
- 대한구강생물학회
- Keywords
- acetyltransferase; transcription; INHAT
- Citation
- International Journal of Oral Biology, v.29, no.3, pp 83 - 86
- Pages
- 4
- Journal Title
- International Journal of Oral Biology
- Volume
- 29
- Number
- 3
- Start Page
- 83
- End Page
- 86
- ISSN
- 1226-7155
2287-6618
- Abstract
- Transcriptional co-activator p300/CBP proteins are involved in various signaling events in the transcriptional processes of proliferation and differentiation. p300/CBP activity can be under aberrant control in many human disease including cancer. The transcriptional regulatory properties of p300/CBP appear to be working through multiple mechanisms. p300/CBP act as protein mediators connecting different transcription factors to the transcriptional machinery. Also , the key property is the presence of histone acetyltransferase(HAT)activity, which can influence chromatin activity by modulating histones. Further research of p300/CBP will continue yield important information on fundamental process involved in transcriptional regulation.
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