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Specialised ribosomes as versatile regulators of gene expressionopen access
- Authors
- Joo, Minju; Yeom, Ji-Hyun; Choi, Younkyung; Jun, Hyeon; Song, Wooseok; Kim, Hyun-Lee; Lee, Kangseok; Shin, Eunkyoung
- Issue Date
- Dec-2022
- Publisher
- Taylor and Francis Ltd.
- Keywords
- divergent rRNA; orthogonal ribosome; post-translational modification; ribosomal protein; ribosome heterogeneity; Specialised ribosome
- Citation
- RNA Biology, v.19, no.1, pp 1103 - 1114
- Pages
- 12
- Journal Title
- RNA Biology
- Volume
- 19
- Number
- 1
- Start Page
- 1103
- End Page
- 1114
- ISSN
- 1547-6286
1555-8584
- Abstract
- The ribosome has long been thought to be a homogeneous cellular machine that constitutively and globally synthesises proteins from mRNA. However, recent studies have revealed that ribosomes are highly heterogeneous, dynamic macromolecular complexes with specialised roles in translational regulation in many organisms across the kingdoms. In this review, we summarise the current understanding of ribosome heterogeneity and the specialised functions of heterogeneous ribosomes. We also discuss specialised translation systems that utilise orthogonal ribosomes. © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
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Collections - College of Natural Sciences > Department of Life Science > 1. Journal Articles
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