Hyaluronic Acid Nanoparticles as a Topical Agent for Treating Psoriasis
DC Field | Value | Language |
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dc.contributor.author | Lee, Wang Hee | - |
dc.contributor.author | Rho, Jun Gi | - |
dc.contributor.author | Yang, Yeyoung | - |
dc.contributor.author | Lee, Seulbi | - |
dc.contributor.author | Kweon, Sohui | - |
dc.contributor.author | Kim, Hyung-Mo | - |
dc.contributor.author | Yoon, Juhwan | - |
dc.contributor.author | Choi, Hongseo | - |
dc.contributor.author | Lee, Eunyoung | - |
dc.contributor.author | Kim, Su Ha | - |
dc.contributor.author | You, Sohee | - |
dc.contributor.author | Song, Yujin | - |
dc.contributor.author | Oh, Young Soo | - |
dc.contributor.author | Kim, Hwan | - |
dc.contributor.author | Han, Hwa Seung | - |
dc.contributor.author | Han, Ji Hye | - |
dc.contributor.author | Jung, Myeongwoo | - |
dc.contributor.author | Park, Young Hwan | - |
dc.contributor.author | Choi, Yang Seon | - |
dc.contributor.author | Han, Sukyoung | - |
dc.contributor.author | Lee, Junho | - |
dc.contributor.author | Choi, Sangdun | - |
dc.contributor.author | Kim, Jung-Woong | - |
dc.contributor.author | Park, Jae Hyung | - |
dc.contributor.author | Lee, Eun Kyung | - |
dc.contributor.author | Song, Woo Keun | - |
dc.contributor.author | Kim, Eunha | - |
dc.contributor.author | Kim, Wook | - |
dc.date.accessioned | 2022-12-09T09:40:21Z | - |
dc.date.available | 2022-12-09T09:40:21Z | - |
dc.date.issued | 2022-12 | - |
dc.identifier.issn | 1936-0851 | - |
dc.identifier.issn | 1936-086X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/59545 | - |
dc.description.abstract | Although conventional topical approaches for treating psoriasis have been offered as an alternative, there are still unmet medical needs such as low skin-penetrating efficacy and off-target adverse effects. A hyaluronic acid nanoparticle (HA-NP) formed by self-assembly of HA-hydrophobic moiety conjugates has been broadly studied as a nanocarrier for long-term and target-specific delivery of drugs, owing to their excellent physicochemical and biological characteristics. Here, we identify HA-NPs as topical therapeutics for treating psoriasis using in vivo skin penetration studies and psoriasis animal models. Transcutaneously administered HA-NPs were found to be accumulated and associated with pro-inflammatory macrophages in the inflamed dermis of a psoriasis mouse model. Importantly, HA-NP exerted potent therapeutic efficacy against psoriasis-like skin dermatitis in a size-dependent manner by suppressing innate immune responses and restoring skin barrier function without overt toxicity signs. The therapeutic efficacy of HA-NPs on psoriasis-like skin dermatitis was due to the outermost hydrophilic HA shell layer of HA-NPs, independent of the molecular weight of HA and hydrophobic moiety, and comparable with that of other conventional psoriasis therapeutics widely used in the clinical settings. Overall, HA-NPs have the potential as a topical nanomedicine for treating psoriasis effectively and safely. © | - |
dc.format.extent | 18 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | American Chemical Society | - |
dc.title | Hyaluronic Acid Nanoparticles as a Topical Agent for Treating Psoriasis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acsnano.2c07843 | - |
dc.identifier.bibliographicCitation | ACS Nano, v.16, no.12, pp 20057 - 20074 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000886816900001 | - |
dc.identifier.scopusid | 2-s2.0-85142313510 | - |
dc.citation.endPage | 20074 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 20057 | - |
dc.citation.title | ACS Nano | - |
dc.citation.volume | 16 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | hyaluronic acid | - |
dc.subject.keywordAuthor | psoriasis | - |
dc.subject.keywordAuthor | self-assembled nanoparticle | - |
dc.subject.keywordAuthor | skin barrier function | - |
dc.subject.keywordAuthor | skin inflammation | - |
dc.subject.keywordAuthor | topical therapeutics | - |
dc.subject.keywordPlus | EPIDERMAL BARRIER | - |
dc.subject.keywordPlus | TIGHT JUNCTIONS | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | DRUG | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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