Hyaluronic Acid Nanoparticles as a Topical Agent for Treating Psoriasis
- Authors
- Lee, Wang Hee; Rho, Jun Gi; Yang, Yeyoung; Lee, Seulbi; Kweon, Sohui; Kim, Hyung-Mo; Yoon, Juhwan; Choi, Hongseo; Lee, Eunyoung; Kim, Su Ha; You, Sohee; Song, Yujin; Oh, Young Soo; Kim, Hwan; Han, Hwa Seung; Han, Ji Hye; Jung, Myeongwoo; Park, Young Hwan; Choi, Yang Seon; Han, Sukyoung; Lee, Junho; Choi, Sangdun; Kim, Jung-Woong; Park, Jae Hyung; Lee, Eun Kyung; Song, Woo Keun; Kim, Eunha; Kim, Wook
- Issue Date
- Dec-2022
- Publisher
- American Chemical Society
- Keywords
- hyaluronic acid; psoriasis; self-assembled nanoparticle; skin barrier function; skin inflammation; topical therapeutics
- Citation
- ACS Nano, v.16, no.12, pp 20057 - 20074
- Pages
- 18
- Journal Title
- ACS Nano
- Volume
- 16
- Number
- 12
- Start Page
- 20057
- End Page
- 20074
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/59545
- DOI
- 10.1021/acsnano.2c07843
- ISSN
- 1936-0851
1936-086X
- Abstract
- Although conventional topical approaches for treating psoriasis have been offered as an alternative, there are still unmet medical needs such as low skin-penetrating efficacy and off-target adverse effects. A hyaluronic acid nanoparticle (HA-NP) formed by self-assembly of HA-hydrophobic moiety conjugates has been broadly studied as a nanocarrier for long-term and target-specific delivery of drugs, owing to their excellent physicochemical and biological characteristics. Here, we identify HA-NPs as topical therapeutics for treating psoriasis using in vivo skin penetration studies and psoriasis animal models. Transcutaneously administered HA-NPs were found to be accumulated and associated with pro-inflammatory macrophages in the inflamed dermis of a psoriasis mouse model. Importantly, HA-NP exerted potent therapeutic efficacy against psoriasis-like skin dermatitis in a size-dependent manner by suppressing innate immune responses and restoring skin barrier function without overt toxicity signs. The therapeutic efficacy of HA-NPs on psoriasis-like skin dermatitis was due to the outermost hydrophilic HA shell layer of HA-NPs, independent of the molecular weight of HA and hydrophobic moiety, and comparable with that of other conventional psoriasis therapeutics widely used in the clinical settings. Overall, HA-NPs have the potential as a topical nanomedicine for treating psoriasis effectively and safely. ©
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