Patterns of patients with polypharmacy in adult population from Koreaopen access
- Authors
- Shin, Woo-Young; Go, Tae-Hwa; Kang, Dae Ryong; Lee, Sei Young; Lee, Won; Kim, Seonah; Lee, Jiewon; Kim, Jung-Ha
- Issue Date
- Oct-2022
- Publisher
- Nature Research
- Citation
- Scientific Reports, v.12, no.1
- Journal Title
- Scientific Reports
- Volume
- 12
- Number
- 1
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/60455
- DOI
- 10.1038/s41598-022-23032-z
- ISSN
- 2045-2322
- Abstract
- Polypharmacy and its rising global prevalence is a growing public health burden. Using a large representative nationwide Korean cohort (N = 761,145), we conducted a retrospective cross-sectional study aiming to identify subpopulations of patients with polypharmacy and characterize their unique patterns through cluster analysis. Patients aged ≥ 30 years who were prescribed at least one medication between 2014 and 2018 were included in our study. Six clusters were identified: cluster 1 mostly included patients who were hospitalized for a long time (4.3 ± 5.3 days); cluster 2 consisted of patients with disabilities (100.0%) and had the highest mean number of prescription drugs (7.7 ± 2.8 medications); cluster 3 was a group of low-income patients (99.9%); cluster 4 was a group of high-income patients (80.2%) who frequently (46.4 ± 25.9 days) visited hospitals/clinics (7.3 ± 2.7 places); cluster 5 was mostly elderly (74.9 ± 9.8 years) females (80.3%); and cluster 6 comprised mostly middle-aged (56.4 ± 1.5 years) males (88.6%) (all P < 0.001). Patients in clusters 1–5 had more prescribed medications and outpatient visit days than those in cluster 6 (all P < 0.001). Given limited health care resources, individuals with any of the identified phenotypes may be preferential candidates for participation in intervention programs for optimal medication use. © 2022, The Author(s).
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