고혈압 복합제 복용환자에서 동일계열약물 중복 현황open accessClass duplication prescriptions in patients taking fixed-dose combination antihypertensives
- Authors
- 구현지; 이지원; 최하은; 제남경; 정경혜
- Issue Date
- 2022
- Publisher
- 한국임상약학회
- Keywords
- Fixed-dose combination antihypertensives; class duplication prescriptions; calcium channel blockers; angiotensin II receptor blockers
- Citation
- 한국임상약학회지, v.32, no.2, pp 125 - 132
- Pages
- 8
- Journal Title
- 한국임상약학회지
- Volume
- 32
- Number
- 2
- Start Page
- 125
- End Page
- 132
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/60740
- DOI
- 10.24304/kjcp.2022.32.1.125
- ISSN
- 1226-6051
2508-786X
- Abstract
- Background: Fixed-dose combinations have the advantage of improving patient compliance, but may increase the risk of duplicateprescriptions. As the use of fixed-dose combination antihypertensives increases, it is necessary to investigate the current status ofclass duplication prescriptions (CDP) in patients taking fixed-dose combination antihypertensives in Korea and to identify factorsassociated with CDP. Methods: We conducted a retrospective observational study using nationally representative claim data.
Hypertensive patients aged 20 years or older taking fixed-dose combination antihypertensives were extracted. Among these patients,patients with CDP were identified. A chi-square test was applied to determine the differences between patients with CDP and non-CDP. The associated factors of CDP were identified through multiple logistic regression. Results: Of the 74,165 patients who wereprescribed fixed-dose combination antihypertensives, 426 patients (0.6%) with CDP were identified. The most commonantihypertensive class associated with CDP was calcium channel blockers (194 patients, 45.5%), followed by angiotensin II receptorblockers (136 patients, 31.9%). Patients aged 75 years or older (odds ratio [OR] 1.83, 95% confidence interval [CI] 1.02-3.52),chronic kidney disease (OR 4.45, 95% CI 2.15-8.25), chronic heart failure (OR 2.71, 95% CI 1.93-3.72), coronary artery disease(OR 2.22, 95% CI 1.60-3.03) and Medical Aid/Patriots and Veterans Insurance (OR 1.49, 95% CI 1.04-2.07) were significantlyassociated with increased CDP. Conclusions: The factors associated with CDP were the elderly, comorbidities, and lowsocioeconomic status. Since CDP can result in negative clinical outcomes, active intervention by the pharmacist is warranted.
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