Tuning Local Coordination Environments of Manganese Single-Atom Nanozymes with Multi-Enzyme Properties for Selective Colorimetric Biosensing
- Authors
- Wang, Y.; Cho, A.; Jia, G.; Cui, X.; Shin, J.; Nam, I.; Noh, K.-J.; Park, B.J.; Huang, R.; Han, J.W.
- Issue Date
- Apr-2023
- Publisher
- John Wiley and Sons Inc
- Keywords
- Biocatalyst; Biosensing; Coordination Environment; Multi-Enzyme Properties; Single-Atom Nanozyme
- Citation
- Angewandte Chemie - International Edition, v.62, no.15
- Journal Title
- Angewandte Chemie - International Edition
- Volume
- 62
- Number
- 15
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/61119
- DOI
- 10.1002/anie.202300119
- ISSN
- 1433-7851
1521-3773
- Abstract
- Single-atom nanozymes (SAzymes) are promising in next-generation nanozymes, nevertheless, how to rationally modulate the microenvironment of SAzymes with controllable multi-enzyme properties is still challenging. Herein, we systematically investigate the relationship between atomic configuration and multi-enzymatic performances. The constructed MnSA−N3-coordinated SAzymes (MnSA−N3−C) exhibits much more remarkable oxidase-, peroxidase-, and glutathione oxidase-like activities than that of MnSA−N4−C. Based on experimental and theoretical results, these multi-enzyme-like behaviors are highly dependent on the coordination number of single atomic Mn sites by local charge polarization. As a consequence, a series of colorimetric biosensing platforms based on MnSA−N3−C SAzymes is successfully built for specific recognition of biological molecules. These findings provide atomic-level insight into the microenvironment of nanozymes, promoting rational design of other demanding biocatalysts. © 2023 Wiley-VCH GmbH.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.