Emerging role for R-loop formation in hepatocellular carcinoma
- Authors
- Baek, Hyojin; Park, Sang-Uk; Kim, Jeongkyu
- Issue Date
- May-2023
- Publisher
- Genetics Society of Korea
- Keywords
- DNA damage and repair; Genome integrity; Hepatocellular carcinoma; R-loop
- Citation
- Genes and Genomics, v.45, no.5, pp 543 - 551
- Pages
- 9
- Journal Title
- Genes and Genomics
- Volume
- 45
- Number
- 5
- Start Page
- 543
- End Page
- 551
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/61120
- DOI
- 10.1007/s13258-022-01360-8
- ISSN
- 1976-9571
2092-9293
- Abstract
- The pathophysiological characteristics of hepatocellular carcinoma (HCC) is closely associated with genomic instability. Genomic instability has long been considered to be a hallmark of both human genetic disease and cancers. It is now well accepted that regulating R-loop formation to minimized levels is one of critical modulation to maintain genome integrity, and that improper regulation of R-loop metabolism causes genomic instability via DNA breakage, ultimately resulting in replicative senescence and even tumorigenesis. Given that R-loop is natural by-product formed during normal transcription condition, and that several types of cancer have defense mechanism against the genomic instability resulted from R-loop formation, modulating functional implication of proteins involved in the intrinsic and specific mechanisms of abnormal R-loop formation in cancers therefore could play an important part in appropriated therapeutic strategies for HCC cohorts. In this review, we highlight the latest understanding on how R-loops promote genomic instability and address how alterations in these pathways link to human HCC. © 2023, The Author(s) under exclusive licence to The Genetics Society of Korea.
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Collections - College of Natural Sciences > Department of Life Science > 1. Journal Articles
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