Warfarin Therapy After Mechanical Valve Replacement: A Tool for Predicting Bleeding Events
- Authors
- Jang, I.; Choo, S.; Kim, K.
- Issue Date
- Mar-2017
- Publisher
- ICR Publishers Ltd.
- Citation
- Journal of Heart Valve Disease, v.26, no.2, pp 215 - 233
- Pages
- 19
- Journal Title
- Journal of Heart Valve Disease
- Volume
- 26
- Number
- 2
- Start Page
- 215
- End Page
- 233
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/6117
- ISSN
- 0966-8519
- Abstract
- METHODS: The retrospective cohort study included 2,453 patients followed up for at least one year after valve replacement surgery, between January 2003 and December 2012. Discriminant analysis was used to assess potential bleeding risk factors out of 31 patient- related and disease-related descriptors. The prediction capability of the descriptors was evaluated based on accuracy, sensitivity,specificity, positive predictive value, and negative predictive value.BACKGROUND AND AIM OF THE STUDY: Mechanical valve replacement is associated with positive outcomes, but patients must undergo life-long anticoagulation therapy with warfarin, which carries a significant risk of bleeding complications. Therefore, a systematic and continuous assessment and supervision of warfarin treatment is essential in such patients, and approaches that can predict the risk of bleeding in advance are required. The study aim was to develop a classification tool to predict bleeding events in South Korean patients with mechanical valve replacement undergoing oral warfarin therapy.RESULTS: A total of 13 descriptors including general, clinical-related and medication-related risk factors was selected as suitable predictors for bleeding risk. A novel classification tool was developed using these risk factors, and evaluated for accuracy (91.5%), sensitivity (80.2%), and specificity (95.2%).CONCLUSIONS: The classification tool developed in the present study can be reliably used in a clinical context to predict bleeding events in patients with mechanical valve replacement undergoing oral warfarin therapy.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Red Cross College of Nursing > Department of Nursing > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.