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Optimization of extraction conditions for active compounds of herbal medicinal formula, DF, by response surface methodologyopen access
- Authors
- Jeong, Birang; Choi, Seong Yeon; Jang, Hyeon Seok; Yoo, Guijae; Kim, Seung Hyun; Kim, Jung-Hwan; Kwon, Yong Soo; Roh, Jong Seong; Yoon, Yoosik; Shin, Soon Shik; Yang, Heejung
- Issue Date
- Jan-2017
- Publisher
- Korean Society of Pharmacognosy
- Keywords
- (+)-pseudoephedrine; (−)-ephedrine; Ephedra intermedia; HPLC; Response surface methodology
- Citation
- Natural Product Sciences, v.23, no.1, pp 9 - 15
- Pages
- 7
- Journal Title
- Natural Product Sciences
- Volume
- 23
- Number
- 1
- Start Page
- 9
- End Page
- 15
- ISSN
- 1226-3907
- Abstract
- DF formula is comprised of three traditional herbs, Ephedra intermedia, Rheum palmatum and Lithospermum erythrorhizon, and locally used for treating of the metabolic diseases, such as obesity and diabetes in Korea. We tried to optimize the extraction conditions of two major components, (−)-ephedrine and (+)-pseudoephedrine, in DF formula using response surface methodology with Box-Behnken design (BBD). The experimental conditions with 70% for EtOH concentrations, 4.8 hour for extraction hours and 8.7 times for the solvent to material ratio were suggested for the optimized extraction of DF formula with the highest amounts of (−)-ephedrine and (+)-pseudoephedrine in the designed model. © 2017, Korean Society of Pharmacognosy. All rights reserved.
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