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Aldose reductase inhibitory activity of quercetin from the stems of Rhododendron mucronulatum for. Albiflorum
- Authors
- Lee, J.; Ryu, H.-S.; Rodriguez, J.P.; Lee, S.
- Issue Date
- 2017
- Publisher
- Korean Society for Applied Biological Chemistry
- Keywords
- Aldose reductase inhibition; High-performance liquid chromatography; Quercetin; Rhododendron mucronulatum for. albiflorum
- Citation
- Journal of Applied Biological Chemistry, v.60, no.1, pp 29 - 33
- Pages
- 5
- Journal Title
- Journal of Applied Biological Chemistry
- Volume
- 60
- Number
- 1
- Start Page
- 29
- End Page
- 33
- ISSN
- 1976-0442
2234-7941
- Abstract
- The methanol extract of Rhododendron mucronulatum for. albiflorum (RMFA) stems inhibited aldose reductase (AR) activity. The RMFA fractions obtained by stepwise extraction with solvents of different polarity were tested for AR inhibition in vitro using the lens of a rat. Among them, the ethyl acetate (EtOAc) fraction inhibited AR more than the other fractions. Quercetin (1) from the EtOAc fraction showed a high AR inhibition with IC50 of 2.11 μM. The stems of RMFA contained the highest amount (5.12 mg/g extract) of quercetin. Our results suggest that RMFA, which contained quercetin, could be a useful material for the development of supplementary functional foods. © The Korean Society for Applied Biological Chemistry 2017.
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