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Development of a chitosan based double layercoated tablet as a platform for colon-specific drug deliveryopen access

Authors
Kim, Min SooYeom, Dong WooKim, Sung RaeYoon, Ho YubKim, Chang HyunSon, Ho YongKim, Jin HanLee, SangkilChoi, Young Wook
Issue Date
Dec-2016
Publisher
DOVE MEDICAL PRESS LTD
Keywords
chitosan; colon-specific delivery; acidification; microflora; factorial design; controlled release
Citation
DRUG DESIGN DEVELOPMENT AND THERAPY, v.11, pp 45 - 57
Pages
13
Journal Title
DRUG DESIGN DEVELOPMENT AND THERAPY
Volume
11
Start Page
45
End Page
57
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/6173
DOI
10.2147/DDDT.S123412
ISSN
1177-8881
Abstract
A double layer-coated colon-specific drug delivery system (DL-CDDS) was developed, which consisted of chitosan (CTN) based polymeric subcoating of the core tablet containing citric acid for microclimate acidification, followed by an enteric coating. The polymeric composition ratio of Eudragit E100 and ethyl cellulose and amount of subcoating were optimized using a twolevel factorial design method. Drug-release characteristics in terms of dissolution efficiency and controlled-release duration were evaluated in various dissolution media, such as simulated colonic fluid in the presence or absence of CTNase. Microflora activation and a stepwise mechanism for drug release were postulated. Consequently, the optimized DL-CDDS showed drug release in a controlled manner by inhibiting drug release in the stomach and intestine, but releasing the drug gradually in the colon (approximately 40% at 10 hours and 92% at 24 hours in CTNasesupplemented simulated colonic fluid), indicating its feasibility as a novel platform for CDD.
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약학대학 (약학부)
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