Serum levels of tnf-α are increased in patients with rotator cuff tear and sleep disturbance
DC Field | Value | Language |
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dc.contributor.author | Cho, C.-H. | - |
dc.contributor.author | Kim, D.-H. | - |
dc.contributor.author | Baek, E.-H. | - |
dc.contributor.author | Kim, D.-H. | - |
dc.date.accessioned | 2023-03-08T10:01:47Z | - |
dc.date.available | 2023-03-08T10:01:47Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 2075-4418 | - |
dc.identifier.issn | 2075-4418 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/62019 | - |
dc.description.abstract | The purpose of this study was to determine serum levels of sleep-related cytokines in patients with rotator cuff tear (RCT) who were experiencing pain-related sleep disturbance. Peripheral blood samples before surgery were collected from 63 study participants and divided into three groups: RCT with sleep disturbance group; SD group (n = 21), RCT with normal sleep group; NS group (n = 21), and patients with chronic shoulder instability; control group (n = 21). Serum concentration levels of interleukin-1α (IL-1α), IL-1β, IL-2, IL-6, IL-8, IL-10, and tumor necrosis factor-α (TNF-α) were measured via ELISA. The associations between serum levels of sleep-related cytokines and clinical scores and the Pittsburgh Sleep Quality Index (PSQI) were analyzed. Serum concentration levels of TNF-α were significantly higher in the SD group compared with those of the NS and control groups (p ≤ 0.001 and 0.05). Serum levels of IL-8 and IL-10 were significantly higher in the SD group compared with those of control group (p = 0.01 and = 0.05), but did not differ significantly from that of the NS group. There were no associations between serum levels of sleep-related cytokines and all clinical scores. The current findings suggest that TNF-α may be associated with sleep disturbance in patients with RCT. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Serum levels of tnf-α are increased in patients with rotator cuff tear and sleep disturbance | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/diagnostics11122215 | - |
dc.identifier.bibliographicCitation | Diagnostics, v.11, no.12 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000737113100001 | - |
dc.identifier.scopusid | 2-s2.0-85120177374 | - |
dc.citation.number | 12 | - |
dc.citation.title | Diagnostics | - |
dc.citation.volume | 11 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | Cytokine | - |
dc.subject.keywordAuthor | Rotator cuff | - |
dc.subject.keywordAuthor | Sleep | - |
dc.subject.keywordAuthor | Tumor necrosis factor-α | - |
dc.subject.keywordPlus | SHOULDER PAIN | - |
dc.subject.keywordPlus | INFLAMMATORY CYTOKINES | - |
dc.subject.keywordPlus | DEPRESSION | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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