Serum levels of tnf-α are increased in patients with rotator cuff tear and sleep disturbanceopen access
- Authors
- Cho, C.-H.; Kim, D.-H.; Baek, E.-H.; Kim, D.-H.
- Issue Date
- Dec-2021
- Publisher
- MDPI
- Keywords
- Cytokine; Rotator cuff; Sleep; Tumor necrosis factor-α
- Citation
- Diagnostics, v.11, no.12
- Journal Title
- Diagnostics
- Volume
- 11
- Number
- 12
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/62019
- DOI
- 10.3390/diagnostics11122215
- ISSN
- 2075-4418
2075-4418
- Abstract
- The purpose of this study was to determine serum levels of sleep-related cytokines in patients with rotator cuff tear (RCT) who were experiencing pain-related sleep disturbance. Peripheral blood samples before surgery were collected from 63 study participants and divided into three groups: RCT with sleep disturbance group; SD group (n = 21), RCT with normal sleep group; NS group (n = 21), and patients with chronic shoulder instability; control group (n = 21). Serum concentration levels of interleukin-1α (IL-1α), IL-1β, IL-2, IL-6, IL-8, IL-10, and tumor necrosis factor-α (TNF-α) were measured via ELISA. The associations between serum levels of sleep-related cytokines and clinical scores and the Pittsburgh Sleep Quality Index (PSQI) were analyzed. Serum concentration levels of TNF-α were significantly higher in the SD group compared with those of the NS and control groups (p ≤ 0.001 and 0.05). Serum levels of IL-8 and IL-10 were significantly higher in the SD group compared with those of control group (p = 0.01 and = 0.05), but did not differ significantly from that of the NS group. There were no associations between serum levels of sleep-related cytokines and all clinical scores. The current findings suggest that TNF-α may be associated with sleep disturbance in patients with RCT. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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