Influenza-associated Neurologic Complications in Hospitalized Pediatric Patients A Multicenter Retrospective Study in Republic of Korea
DC Field | Value | Language |
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dc.contributor.author | Choi, Gwang-Jun | - |
dc.contributor.author | Park, Ji Young | - |
dc.contributor.author | Choi, Joon-Sik | - |
dc.contributor.author | Choi, Sae Rom | - |
dc.contributor.author | Kim, Dongsub | - |
dc.contributor.author | Lee, Jun Hwa | - |
dc.contributor.author | Woo, Young-Jong | - |
dc.contributor.author | Lee, Jeehun | - |
dc.contributor.author | Kim, Yae-Jean | - |
dc.date.accessioned | 2023-03-08T10:02:49Z | - |
dc.date.available | 2023-03-08T10:02:49Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 0891-3668 | - |
dc.identifier.issn | 1532-0987 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/62027 | - |
dc.description.abstract | Background: The rates of influenza-associated neurologic complications are variable among studies, and a difference has been observed between the Western and Asian countries. The study aims to evaluate the frequency and characteristics of influenza-associated neurologic complications. Methods: We performed a retrospective review of hospitalized cases of influenza infection from October 2010 to April 2017 from 3 referral hospitals. Results: A total of 1988 influenza cases were identified. Influenza-associated neurologic complications were 161 cases (8.1%); influenza virus A was detected in 113 (70.2%) cases, B in 47 (29.2%) cases and both A and B in 1 case (0.6%). Twenty-four patients (15%) had underlying neurologic diseases. The most common diagnosis was a simple febrile convulsion (44%), followed by complex febrile convulsion (29%), fever-provoked seizure under pre-existing neurologic disease or afebrile seizure (14%), encephalopathy/encephalitis (8%) and meningitis (5%). Most of the patients fully recovered (96%). Three patients (1.9%) died of myocarditis (n = 1), encephalopathy (n = 1), and simultaneous encephalitis and myocarditis (n = 1). Pre-existing neurologic disease, age groups of 6 months to 6 years and 6-12 years were a risk factor of influenza-associated neurologic complications with an adjusted odds ratio of 5.41 (95% confidence interval [CI] 3.23-9.06, P < 0.001), 12.99 (95% CI 1.77-95.19, P = 0.01) and 8.54 (95% CI 1.14-64.79, P = 0.04), respectively. There was no association between neuropsychiatric adverse events and oseltamivir prescription (P = 0.17). Conclusions: Influenza-associated neurologic complications are not uncommon, and most patients fully recovered. The frequency of influenza-associated neurologic complications in Korean children was not significantly different from that of children in Western countries. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.title | Influenza-associated Neurologic Complications in Hospitalized Pediatric Patients A Multicenter Retrospective Study in Republic of Korea | - |
dc.type | Article | - |
dc.identifier.doi | 10.1097/INF.0000000000003332 | - |
dc.identifier.bibliographicCitation | PEDIATRIC INFECTIOUS DISEASE JOURNAL, v.40, no.12, pp E466 - E471 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000716559300004 | - |
dc.identifier.scopusid | 2-s2.0-85121632685 | - |
dc.citation.endPage | E471 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | E466 | - |
dc.citation.title | PEDIATRIC INFECTIOUS DISEASE JOURNAL | - |
dc.citation.volume | 40 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | encephalopathy | - |
dc.subject.keywordAuthor | encephalitis | - |
dc.subject.keywordAuthor | seizures | - |
dc.subject.keywordAuthor | meningitis | - |
dc.subject.keywordAuthor | oseltamivir | - |
dc.subject.keywordPlus | SEASONAL INFLUENZA | - |
dc.subject.keywordPlus | ABNORMAL-BEHAVIOR | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | MANIFESTATIONS | - |
dc.subject.keywordPlus | ENCEPHALOPATHY | - |
dc.subject.keywordPlus | OSELTAMIVIR | - |
dc.subject.keywordPlus | ADULTS | - |
dc.subject.keywordPlus | VIRUS | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Pediatrics | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Pediatrics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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