Influenza-associated Neurologic Complications in Hospitalized Pediatric Patients A Multicenter Retrospective Study in Republic of Korea
- Authors
- Choi, Gwang-Jun; Park, Ji Young; Choi, Joon-Sik; Choi, Sae Rom; Kim, Dongsub; Lee, Jun Hwa; Woo, Young-Jong; Lee, Jeehun; Kim, Yae-Jean
- Issue Date
- Dec-2021
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- encephalopathy; encephalitis; seizures; meningitis; oseltamivir
- Citation
- PEDIATRIC INFECTIOUS DISEASE JOURNAL, v.40, no.12, pp E466 - E471
- Journal Title
- PEDIATRIC INFECTIOUS DISEASE JOURNAL
- Volume
- 40
- Number
- 12
- Start Page
- E466
- End Page
- E471
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/62027
- DOI
- 10.1097/INF.0000000000003332
- ISSN
- 0891-3668
1532-0987
- Abstract
- Background: The rates of influenza-associated neurologic complications are variable among studies, and a difference has been observed between the Western and Asian countries. The study aims to evaluate the frequency and characteristics of influenza-associated neurologic complications. Methods: We performed a retrospective review of hospitalized cases of influenza infection from October 2010 to April 2017 from 3 referral hospitals. Results: A total of 1988 influenza cases were identified. Influenza-associated neurologic complications were 161 cases (8.1%); influenza virus A was detected in 113 (70.2%) cases, B in 47 (29.2%) cases and both A and B in 1 case (0.6%). Twenty-four patients (15%) had underlying neurologic diseases. The most common diagnosis was a simple febrile convulsion (44%), followed by complex febrile convulsion (29%), fever-provoked seizure under pre-existing neurologic disease or afebrile seizure (14%), encephalopathy/encephalitis (8%) and meningitis (5%). Most of the patients fully recovered (96%). Three patients (1.9%) died of myocarditis (n = 1), encephalopathy (n = 1), and simultaneous encephalitis and myocarditis (n = 1). Pre-existing neurologic disease, age groups of 6 months to 6 years and 6-12 years were a risk factor of influenza-associated neurologic complications with an adjusted odds ratio of 5.41 (95% confidence interval [CI] 3.23-9.06, P < 0.001), 12.99 (95% CI 1.77-95.19, P = 0.01) and 8.54 (95% CI 1.14-64.79, P = 0.04), respectively. There was no association between neuropsychiatric adverse events and oseltamivir prescription (P = 0.17). Conclusions: Influenza-associated neurologic complications are not uncommon, and most patients fully recovered. The frequency of influenza-associated neurologic complications in Korean children was not significantly different from that of children in Western countries.
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