Comparison of clinical characteristics and outcomes of younger and elderly patients with severe covid-19 in korea: A retrospective multicenter study
- Authors
- Seong, Gil Myeong; Baek, Ae-Rin; Baek, Moon Seong; Kim, Won-Young; Kim, Jin Hyoung; Lee, Bo Young; Na, Yong Sub; Lee, Song-I
- Issue Date
- Dec-2021
- Publisher
- MDPI
- Keywords
- Aged; COVID-19; Elderly
- Citation
- Journal of Personalized Medicine, v.11, no.12
- Journal Title
- Journal of Personalized Medicine
- Volume
- 11
- Number
- 12
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/62068
- DOI
- 10.3390/JPM11121258
- ISSN
- 2075-4426
2075-4426
- Abstract
- Old age is associated with disease severity and poor prognosis among coronavirus disease 2019 (COVID-19) cases; however, characteristics of elderly patients with severe COVID-19 are limited. We aimed to assess the clinical characteristics and outcomes of patients hospitalized with severe COVID-19 at tertiary care centers in South Korea. This retrospective multicenter study included patients with severe COVID-19 who were admitted at seven hospitals in South Korea from 2 February 2020 to 28 February 2021. The Cox regression analyses were performed to assess factors associated with the in-hospital mortality. Of 488 patients with severe COVID-19, 318 (65.2%) were elderly (≥65 years). The older patient group had more underlying diseases and a higher severity score than the younger patient group. The older patient group had a higher in-hospital mortality rate than the younger patient group (25.5% versus 4.7%, p-value < 0.001). The in-hospital mortality risk factors among patients with severe COVID-19 included age, acute physiology and chronic health evaluation II score, presence of diabetes and chronic obstructive lung disease, high white blood cell count, low neutrophil-lymphocyte ratio and platelet count, do-not-resuscitate order, and treatment with invasive mechanical ventilation. In addition to old age, disease severity and examination results must be considered in treatment decision-making. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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