환자 맞춤형 종양 미세환경 모사 모델들Patient-Specific Tumor Microenvironment Models
- Authors
- 이정우; 김지아; 신영재; 지병훈; 김정훈; 최세영
- Issue Date
- Nov-2021
- Publisher
- 대한비뇨기종양학회
- Keywords
- 3D tumor model; Patient-derived explant; Tissue engineering; Microfluidics
- Citation
- 대한비뇨기종양학술지, v.19, no.4, pp 197 - 222
- Pages
- 26
- Journal Title
- 대한비뇨기종양학술지
- Volume
- 19
- Number
- 4
- Start Page
- 197
- End Page
- 222
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/62082
- DOI
- 10.22465/kjuo.2021.19.4.197
- ISSN
- 2234-4977
- Abstract
- The heterogeneity of cancer makes it difficult to predict the prognosis of treatment. There is still a lack of preclinical model systems that reflect the clinical characteristics of patients who have heterogenetic tumors. Advances in 3-dimentional (3D) cell culture are leading to discoveries that occur in the development and progression of cancer that has not been known. There are many models including patient-derived xenograft, patient-derived organoid and spheroid, patient-derived explant, scaffold-based model, and system-based model. Each 3D model has its strengths and limitations. One model cannot answer every question, so it seems most reasonable to approach multiple models when studying cancer heterogeneity. Hopefully, 3D tumor modeling will make tremendous progress on this path by fusion of innovative biomaterials and advanced modeling techniques that can partially mimic the heterogeneous environment of real tumors.
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