Organophosphorus pesticides exert estrogen receptor agonistic effect determined using Organization for Economic Cooperation and Development PBTG455, and induce estrogen receptor-dependent adipogenesis of 3T3-L1 adipocytes
DC Field | Value | Language |
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dc.contributor.author | Kim, Jin Tae | - |
dc.contributor.author | Lee, Hong Jin | - |
dc.contributor.author | Lee, Hee-Seok | - |
dc.date.accessioned | 2023-03-08T10:33:59Z | - |
dc.date.available | 2023-03-08T10:33:59Z | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 0269-7491 | - |
dc.identifier.issn | 1873-6424 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/62224 | - |
dc.description.abstract | Various chemicals containing pesticides can induce adipogenesis and cause obesity. Organophosphorus pesticides have been used for pest control. Here, we investigated the estrogen receptor (ER)-dependent adipogenesis-inducing effect of representative organophosphorus pesticides (OPs), diazinon, phoxim, terbufos and tolclofos-methyl in 3T3-L1 adipocytes. Four OPs exhibited ER agonistic effect, determined using the OECD Performance Based Test Guideline No. 455; in vitro ER stably transfected transactivation assay using ERα-HeLa-9903 cell line, through binding affinity to ERα. Additionally, they increased lipid droplet accumulation in a dose-dependent manner, which was suppressed by ICI182,780, a well-known ER antagonist. Four OPs treatment induced peroxisome proliferator-activated receptor gamma (PPARγ), CCAAT/enhancer-binding protein alpha (C/EBPα), and perilipin expression. Furthermore, PPARγ, C/EBPα and perilipin expression was inhibited by co-treatment with ICI182,780. The increased mRNA expression of lipoprotein lipase and fatty acid synthase by four OPs was suppressed by co-treatment with ICI182,780. These results indicated that diazinon, phoxim, terbufos, and tolclofos-methyl might have adipogenesis-inducing effect mediated by interacting with ER. © 2021 Elsevier Ltd | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier Ltd | - |
dc.title | Organophosphorus pesticides exert estrogen receptor agonistic effect determined using Organization for Economic Cooperation and Development PBTG455, and induce estrogen receptor-dependent adipogenesis of 3T3-L1 adipocytes | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.envpol.2021.117090 | - |
dc.identifier.bibliographicCitation | Environmental Pollution, v.283 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000663131000003 | - |
dc.identifier.scopusid | 2-s2.0-85104391924 | - |
dc.citation.title | Environmental Pollution | - |
dc.citation.volume | 283 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Adipogenesis | - |
dc.subject.keywordAuthor | Agonist | - |
dc.subject.keywordAuthor | Estrogen receptor | - |
dc.subject.keywordAuthor | Organophosphorus pesticides | - |
dc.subject.keywordPlus | ENDOCRINE-DISRUPTING CHEMICALSCELL-PROLIFERATIONALPHAWATERINSECTICIDEEXPOSUREDIAZINONASSAYSGAMMABETA | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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