Usefulness of Post-bronchoscopy Sputum Culture for Diagnosis of Nontuberculous Mycobacterial Pulmonary Diseaseopen access
- Authors
- Gu Kang-Mo; Kang Hye-Rin; Park Jimyung; Kwak Nakwon; Yim Jae-Joon
- Issue Date
- Aug-2021
- Publisher
- 대한의학회
- Keywords
- NTM-PD; Post-Bronchoscopy Sputum; Diagnostic Yield
- Citation
- Journal of Korean Medical Science, v.36, no.31, pp 1 - 8
- Pages
- 8
- Journal Title
- Journal of Korean Medical Science
- Volume
- 36
- Number
- 31
- Start Page
- 1
- End Page
- 8
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/62227
- DOI
- 10.3346/jkms.2021.36.e202
- ISSN
- 1011-8934
1598-6357
- Abstract
- Background: Bronchoscopy is recommended for patients with suspected nontuberculous mycobacterial pulmonary disease (NTM-PD) whose sputum culture results are consistently negative or from whom adequate sputum samples cannot be obtained. Post-bronchoscopy sputum (PBS) collection is recommended for patients with suspected tuberculosis who undergo bronchoscopy. However, it remains unclear whether PBS collection can increase the diagnostic yield of NTM-PD.
Methods: Patients with suspected NTM-PD who underwent diagnostic bronchoscopy from January 1, 2017 to June 30, 2020 at the Seoul National University Hospital were included in the study. They were divided into the sputum culture-negative and scanty sputum groups.
The results of mycobacterial cultures from bronchial washing specimens and PBS were compared between these groups.
Results: In total, 141 patients were included in the study; there were 39 and 102 patients in the sputum culture-negative and scanty sputum groups, respectively. Nontuberculous mycobacteria were cultured from bronchial washing specimens collected from 38.3% (54/141) of all patients (30.7% [12/39] patients in the sputum culture-negative group and 41.2% [42/102] patients in the scanty sputum group; P = 0.345). Nontuberculous mycobacteria were exclusively cultured from PBS collected from 3.5% (5/141) of all patients (7.7% [3/39] patients in the sputum culture-negative group and 2.0% [2/102] patients in the scanty sputum group; P = 0.255).
Conclusions: Additional PBS collection improved diagnostic yield marginally in patients with suspected NTM-PD who undergo bronchoscopy
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