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Comparison of endoscopically determined gross tumor volume and metabolic tumor volume in esophageal cancer

Authors
Lee, Tae HoonRyoo, Hyun GeeLee, ReereePaeng, Jin ChulChung, HyunsooKim, Hak Jae
Issue Date
18-Jun-2021
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Keywords
endoscopy; esophageal cancer; positron emission tomography scan; tumor volume
Citation
MEDICINE, v.100, no.24, pp e26338
Journal Title
MEDICINE
Volume
100
Number
24
Start Page
e26338
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/62359
DOI
10.1097/MD.0000000000026338
ISSN
0025-7974
1536-5964
Abstract
The purpose of this study is to compare the longitudinal location of endoscopically-defined gross tumor volume (GTV) and positron emission tomography-based metabolic tumor volume (MTV) of esophageal cancer. A retrospective review of medical records was performed of the nine patients who underwent endoscopic placement of fiducial markers for radiotherapy of esophageal squamous cell carcinoma. Endoscopic hemoclips were used as the fiducial markers, and GTV was newly delineated solely based on the locations of the fiducial markers. The standardized uptake value (SUV) threshold corresponding to the superior and inferior borders of GTV was defined as the highest threshold that made MTV reach each border of GTV. The median fixed relative and absolute thresholds were 32% and 3.8, respectively. The coefficient of variation of the threshold values was 0.781 for the fixed relative threshold method and 0.400 for the fixed absolute threshold method, indicating more consistent results from the fixed absolute threshold method. All but two GTV borders were included in MTV with a SUV threshold of 2.5. Esophageal tumors with a maximum SUV > 20 tended to have closer threshold values corresponding to the GTV borders to 2.5 (median 2.8 vs 3.6, P = .069). The fixed absolute threshold method was suitable for determining the MTV threshold for esophageal lesions. A SUV of 2.5 was appropriate for esophageal tumors with a maximum SUV > 20. Endoscopic hemoclips were stable enough for using as the fiducial marker.
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