Changes in the component sugar and immunostimulating activity of polysaccharides isolated from Dendrobium officinale in the pretreatments
DC Field | Value | Language |
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dc.contributor.author | Jo, Kyungae | - |
dc.contributor.author | Kim, Singeun | - |
dc.contributor.author | Yu, Kwang-Won | - |
dc.contributor.author | Chung, Young Bae | - |
dc.contributor.author | Kim, Woo Jung | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.contributor.author | Kim, Hoon | - |
dc.date.accessioned | 2023-03-08T11:52:18Z | - |
dc.date.available | 2023-03-08T11:52:18Z | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 0022-5142 | - |
dc.identifier.issn | 1097-0010 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/62718 | - |
dc.description.abstract | BACKGROUND To isolate polysaccharides with enhanced immunostimulatory activity from Dendrobium officinale, which is used as a herbal medicine in China and Southeast Asia, D. officinale (DO) was pretreated with organic solvents (DOOS) or puffing at 7.5 and 9.0 kg(f) (7.5DO and 9DO). Hot-water extracts (DOOS-HW, 7.5DO-HW and 9DO-HW) were prepared from each pretreated DO, along with non-pretreated DO, and crude polysaccharides (DO-CP, DOOS-CP, 7.5DO-CP and 9DO-CP) were fractionated from each hot-water extract using ethanol (five volumes). RESULTS When their immunostimulatory activities were compared by macrophage stimulation and intestinal immune system modulation via Peyer's patches, DOOS-CP showed more potent activity than DO-CP. However, crude polysaccharides fractionated from puffed DO showed significantly lower activity than non-puffed DO and DOOS. The most active polysaccharide contained 95% or more neutral sugar, and the composition ratio of mannose and glucose was 3.0, whereas the lowest polysaccharide content was 2.0 or less. In addition, DOOS-CP was a somewhat refined fraction containing a major peak, representing a molecular weight of 250 kDa, despite being a crude polysaccharide. CONCLUSION These results suggest that pretreatment of D. officinale with organic solvents may enhance the immunostimulatory activity of polysaccharides and affect the mannose/glucose ratio of polysaccharides, which plays an important role in immunostimulation. (c) 2021 Society of Chemical Industry | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | Changes in the component sugar and immunostimulating activity of polysaccharides isolated from Dendrobium officinale in the pretreatments | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/jsfa.11642 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, v.102, no.7, pp 3021 - 3028 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000721454600001 | - |
dc.identifier.scopusid | 2-s2.0-85119680205 | - |
dc.citation.endPage | 3028 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 3021 | - |
dc.citation.title | JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE | - |
dc.citation.volume | 102 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Dendrobium officinale | - |
dc.subject.keywordAuthor | physicochemical pretreatment | - |
dc.subject.keywordAuthor | polysaccharide | - |
dc.subject.keywordAuthor | immunostimulating activity | - |
dc.subject.keywordAuthor | glucomannan | - |
dc.subject.keywordPlus | NITRIC-OXIDE PRODUCTION | - |
dc.subject.keywordPlus | MACROPHAGE ACTIVATION | - |
dc.subject.keywordPlus | BIOACTIVITIES | - |
dc.relation.journalResearchArea | Agriculture | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Agriculture, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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