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Mucin in cancer: a stealth cloak for cancer cellsopen access

Authors
Wi, Dong-HanCha, Jong-HoJung, Youn-Sang
Issue Date
Jul-2021
Publisher
생화학분자생물학회
Keywords
Anti-cancer therapy; Mucin; Mucinous carcinoma;  Preclinical mouse model; Tumorigenesis
Citation
BMB Reports, v.54, no.7, pp 344 - 355
Pages
12
Journal Title
BMB Reports
Volume
54
Number
7
Start Page
344
End Page
355
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/62901
DOI
10.5483/BMBRep.2021.54.7.064
ISSN
1976-6696
1976-670X
Abstract
Mucins are high molecular-weight epithelial glycoproteins and are implicated in many physiological processes, including epithelial cell protection, signaling transduction, and tissue homeostasis. Abnormality of mucus expression and structure contributes to biological properties related to human cancer progression. Tumor growth sites induce inhospitable conditions. Many kinds of research suggest that mucins provide a microenvironment to avoid hypoxia, acidic, and other biological conditions that promote cancer progression. Given that the mucus layer captures growth factors or cytokines, we propose that mucin helps to ameliorate inhospitable conditions in tumor-growing sites. Additionally, the composition and structure of mucins enable them to mimic the surface of normal epithelial cells, allowing tumor cells to escape from immune surveillance. Indeed, human cancers such as mucinous carcinoma, show a higher incidence of invasion to adjacent organs and lymph node metastasis than do non-mucinous carcinoma. In this minireview, we discuss how mucin provides a tumor-friendly environment and contributes to increased cancer malignancy in mucinous carcinoma.
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Jung, Youn-Sang
자연과학대학 (생명과학과)
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