Combination Treatment with Human Adipose Tissue Stem Cell-derived Exosomes and Fractional CO2 Laser for Acne Scars: A 12-week Prospective, Double-blind, Randomized, Split-face Study
- Authors
- Kwon, Hyuck Hoon; Yang, Steven Hoseong; Lee, Joon; Park, Byung Cheol; Park, Kui Young; Jung, Jae Yoon; Bae, Youin; Park, Gyeong-Hun
- Issue Date
- Nov-2020
- Publisher
- ACTA DERMATO-VENEREOLOGICA
- Keywords
- adipose tissue stem cell-derived exosomes; acne scar; fractional laser
- Citation
- ACTA DERMATO-VENEREOLOGICA, v.100, no.18, pp 1 - 8
- Pages
- 8
- Journal Title
- ACTA DERMATO-VENEREOLOGICA
- Volume
- 100
- Number
- 18
- Start Page
- 1
- End Page
- 8
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/63158
- DOI
- 10.2340/00015555-3666
- ISSN
- 0001-5555
1651-2057
- Abstract
- A variety of applications of human adipose tissue stem cell-derived exosomes have been suggested as novel cell-free therapeutic strategies in the regenerative and aesthetic medical fields. This study evaluated the clinical efficacy and safety of adipose tissue stem cell-derived exosomes as an adjuvant therapy after application of fractional CO2 laser for acne scars. A 12-week prospective, double-blind, randomized, split-face trial was performed. A total of 25 patients received three consecutive treatment sessions of fractional CO2 laser to the whole face, with a follow-up evaluation. Post-laser treatment regimens were applied; for each patient, one side of the face was treated with adipose tissue stem cell-derived exosomes gel and the other side was treated with control gel. Adipose tissue stem cell-derived exosomes-treated sides had achieved a significantly greater improvement than the control sides at the final follow-up visit (percentage reduction in echelle d'evaluation clinique des cicatrices d'acne scores: 32.5 vs 19.9%, p < 0.01). Treatment-related erythema was milder, and post-treatment downtime was shorter on the human adipose tissue stem cell-derived exosomes-treated side. In conclusion, the combined use of this novel material with resurfacing devices would provide synergistic effects on both the efficacy and safety of atrophic acne scar treatments.
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