Comparing feasibility of low-tube-voltage protocol with low-iodine-concentration contrast and high-tube-voltage protocol with high-iodine-concentration contrast in coronary computed tomography angiographyopen access
- Authors
- Cha, Min Jae; Kim, Sung Mok; Ahn, Tae Ran; Choe, Yeon Hyeon
- Issue Date
- Jul-2020
- Publisher
- PUBLIC LIBRARY SCIENCE
- Citation
- PLOS ONE, v.15, no.7
- Journal Title
- PLOS ONE
- Volume
- 15
- Number
- 7
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/63373
- DOI
- 10.1371/journal.pone.0236108
- ISSN
- 1932-6203
- Abstract
- Background To investigate the feasibility of a low tube voltage (80 kVp) protocol with low concentration contrast media (CM) (iodixanol 320 mgl/ml) as compared with a high tube voltage (100 kVp) protocol with high concentration CM (iomeprol 400 mgl/ml) in coronary CT angiography (CCTA) for patients with body mass index less than 30. Materials and methods A total of 93 patients were randomly assigned into three groups and underwent CCTA as follows: Group A) 100 kVp, 100-350 mAs, 400 mgl/ml CM at 4ml/s, and reconstructed with filtered back projection; Group B and C) 80 kVp, 100-450 mAs, 320 mgl/ml CM at 4 ml/s and 5 ml/s, respectively and reconstructed with iterative reconstruction. Objective and subjective image quality (IQ) was analyzed. Results The image noise, intravascular attenuation, signal-to-noise ratio and contrast-to-noise ratio of major coronary arteries did not differ significantly among three groups. Subjective IQ analyses on vascular attenuation and image noise did not differ significantly, either (all ofp> 0.05). Qualitative IQ of Group B and C was non-inferior to that of Group A. Substantial reduction of radiation exposure was achieved in group B (2.60 +/- 0.48 mSv) and C (2.72 +/- 0.54 mSv), compared with group A (3.58 +/- 0.67 mSv) (p< 0.05). Conclusion CCTA at 80 kVp with 320 mgl/ml CM and iterative reconstruction is feasible, achieving radiation dose reduction, while preserving IQ.
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