CRISPR and Target-Specific DNA Endonucleases for Efficient DNA Knock-in in Eukaryotic Genomes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Seung Hwan | - |
dc.contributor.author | Kim, Sunghyun | - |
dc.contributor.author | Hur, Junho K. | - |
dc.date.accessioned | 2023-03-08T15:46:41Z | - |
dc.date.available | 2023-03-08T15:46:41Z | - |
dc.date.issued | 2018-11 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.issn | 0219-1032 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/63822 | - |
dc.description.abstract | The discovery and mechanistic understanding of target-specific genome engineering technologies has led to extremely effective and specific genome editing in higher organisms. Target-specific genetic modification technology is expected to have a leading position in future gene therapy development, and has a ripple effect on various basic and applied studies. However, several problems remain and hinder efficient and specific editing of target genomic loci. The issues are particularly critical in precise targeted insertion of external DNA sequences into genomes. Here, we discuss some recent efforts to overcome such problems and present a perspective of future genome editing technologies. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.title | CRISPR and Target-Specific DNA Endonucleases for Efficient DNA Knock-in in Eukaryotic Genomes | - |
dc.type | Article | - |
dc.identifier.doi | 10.14348/molcells.2018.0408 | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.41, no.11, pp 943 - 952 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000451324000002 | - |
dc.identifier.scopusid | 2-s2.0-85057540935 | - |
dc.citation.endPage | 952 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 943 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 41 | - |
dc.identifier.url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277560/ | - |
dc.type.docType | Review | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | CRISPR | - |
dc.subject.keywordAuthor | DNA double-strand break | - |
dc.subject.keywordAuthor | genome engineering | - |
dc.subject.keywordAuthor | knock-in | - |
dc.subject.keywordAuthor | target specific endonuclease | - |
dc.subject.keywordPlus | HOMOLOGOUS RECOMBINATION | - |
dc.subject.keywordPlus | BREAK REPAIR | - |
dc.subject.keywordPlus | BASE | - |
dc.subject.keywordPlus | CAS9 | - |
dc.subject.keywordPlus | NUCLEASES | - |
dc.subject.keywordPlus | TALEN | - |
dc.subject.keywordPlus | ZEBRAFISH | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | SYSTEMS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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