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CRISPR and Target-Specific DNA Endonucleases for Efficient DNA Knock-in in Eukaryotic Genomes
- Authors
- Lee, Seung Hwan; Kim, Sunghyun; Hur, Junho K.
- Issue Date
- Nov-2018
- Publisher
- KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
- Keywords
- CRISPR; DNA double-strand break; genome engineering; knock-in; target specific endonuclease
- Citation
- MOLECULES AND CELLS, v.41, no.11, pp 943 - 952
- Pages
- 10
- Journal Title
- MOLECULES AND CELLS
- Volume
- 41
- Number
- 11
- Start Page
- 943
- End Page
- 952
- ISSN
- 1016-8478
0219-1032
- Abstract
- The discovery and mechanistic understanding of target-specific genome engineering technologies has led to extremely effective and specific genome editing in higher organisms. Target-specific genetic modification technology is expected to have a leading position in future gene therapy development, and has a ripple effect on various basic and applied studies. However, several problems remain and hinder efficient and specific editing of target genomic loci. The issues are particularly critical in precise targeted insertion of external DNA sequences into genomes. Here, we discuss some recent efforts to overcome such problems and present a perspective of future genome editing technologies.
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