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The histone variant macroH2A1 is a splicing-modulated caretaker of genome integrity and tumor growthopen access
- Issue Date
- Jun-2018
- Publisher
- TAYLOR & FRANCIS INC
- Citation
- MOLECULAR & CELLULAR ONCOLOGY, v.5, no.3
- Journal Title
- MOLECULAR & CELLULAR ONCOLOGY
- Volume
- 5
- Number
- 3
- ISSN
- 2372-3556
2372-3548
- Abstract
- The macroH2A1.2 histone variant facilitates the response to replication stress with implications for genome maintenance and cell growth. A mutually exclusive splice variant, macroH2A1.1, has opposing effects on DNA repair outcome and proliferation. Here we discuss the potential impact of splicing-modulated macroH2A1 chromatin organization for cell function and malignant transformation.
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Collections - College of Natural Sciences > Department of Life Science > 1. Journal Articles
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