A transfer-RNA-derived small RNA regulates ribosome biogenesis
DC Field | Value | Language |
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dc.contributor.author | Kim, Hak Kyun | - |
dc.contributor.author | Fuchs, Gabriele | - |
dc.contributor.author | Wang, Shengchun | - |
dc.contributor.author | Wei, Wei | - |
dc.contributor.author | Zhang, Yue | - |
dc.contributor.author | Park, Hyesuk | - |
dc.contributor.author | Roy-Chaudhuri, Biswajoy | - |
dc.contributor.author | Li, Pan | - |
dc.contributor.author | Xu, Jianpeng | - |
dc.contributor.author | Chu, Kirk | - |
dc.contributor.author | Zhang, Feijie | - |
dc.contributor.author | Chua, Mei-Sze | - |
dc.contributor.author | So, Samuel | - |
dc.contributor.author | Zhang, Qiangfeng Cliff | - |
dc.contributor.author | Sarnow, Peter | - |
dc.contributor.author | Kay, Mark A. | - |
dc.date.accessioned | 2023-03-08T15:58:31Z | - |
dc.date.available | 2023-03-08T15:58:31Z | - |
dc.date.issued | 2017-12 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.issn | 1476-4687 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/63941 | - |
dc.description.abstract | Transfer-RNA-derived small RNAs (tsRNAs; also called tRNA-derived fragments) are an abundant class of small non-coding RNAs whose biological roles are not well understood. Here we show that inhibition of a specific tsRNA, LeuCAG3'tsRNA, induces apoptosis in rapidly dividing cells in vitro and in a patient-derived orthotopic hepatocellular carcinoma model in mice. This tsRNA binds at least two ribosomal protein mRNAs (RPS28 and RPS15) to enhance their translation. A decrease in translation of RPS28 mRNA blocks pre-18S ribosomal RNA processing, resulting in a reduction in the number of 40S ribosomal subunits. These data establish a post-transcriptional mechanism that can fine-tune gene expression during different physiological states and provide a potential new target for treating cancer. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | A transfer-RNA-derived small RNA regulates ribosome biogenesis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/nature25005 | - |
dc.identifier.bibliographicCitation | NATURE, v.552, no.7683, pp 57 - 62 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000417560500042 | - |
dc.identifier.scopusid | 2-s2.0-85041406911 | - |
dc.citation.endPage | 62 | - |
dc.citation.number | 7683 | - |
dc.citation.startPage | 57 | - |
dc.citation.title | NATURE | - |
dc.citation.volume | 552 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | DIAMOND-BLACKFAN ANEMIA | - |
dc.subject.keywordPlus | CELL-PROLIFERATION | - |
dc.subject.keywordPlus | NUCLEIC-ACID | - |
dc.subject.keywordPlus | FRAGMENTS | - |
dc.subject.keywordPlus | REVEALS | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | MATURATION | - |
dc.subject.keywordPlus | EFFICIENT | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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