A transfer-RNA-derived small RNA regulates ribosome biogenesis
- Authors
- Kim, Hak Kyun; Fuchs, Gabriele; Wang, Shengchun; Wei, Wei; Zhang, Yue; Park, Hyesuk; Roy-Chaudhuri, Biswajoy; Li, Pan; Xu, Jianpeng; Chu, Kirk; Zhang, Feijie; Chua, Mei-Sze; So, Samuel; Zhang, Qiangfeng Cliff; Sarnow, Peter; Kay, Mark A.
- Issue Date
- Dec-2017
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- NATURE, v.552, no.7683, pp 57 - 62
- Pages
- 6
- Journal Title
- NATURE
- Volume
- 552
- Number
- 7683
- Start Page
- 57
- End Page
- 62
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/63941
- DOI
- 10.1038/nature25005
- ISSN
- 0028-0836
1476-4687
- Abstract
- Transfer-RNA-derived small RNAs (tsRNAs; also called tRNA-derived fragments) are an abundant class of small non-coding RNAs whose biological roles are not well understood. Here we show that inhibition of a specific tsRNA, LeuCAG3'tsRNA, induces apoptosis in rapidly dividing cells in vitro and in a patient-derived orthotopic hepatocellular carcinoma model in mice. This tsRNA binds at least two ribosomal protein mRNAs (RPS28 and RPS15) to enhance their translation. A decrease in translation of RPS28 mRNA blocks pre-18S ribosomal RNA processing, resulting in a reduction in the number of 40S ribosomal subunits. These data establish a post-transcriptional mechanism that can fine-tune gene expression during different physiological states and provide a potential new target for treating cancer.
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Collections - College of Natural Sciences > Department of Life Science > 1. Journal Articles
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