A pilot multicenter study evaluating the expression of p53 and ki-67 in gastric tumors and their utility for guiding treatment strategy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Baek, I.H. | - |
dc.contributor.author | Kim, K.O. | - |
dc.contributor.author | Kim, J.W. | - |
dc.contributor.author | Min, K.W. | - |
dc.date.accessioned | 2023-03-08T15:59:22Z | - |
dc.date.available | 2023-03-08T15:59:22Z | - |
dc.date.issued | 2017-12 | - |
dc.identifier.issn | 0000-0000 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/63949 | - |
dc.description.abstract | Background: p53 mutation is the most common genetic alteration in cancers and influences clinical progression. Ki-67 protein is a cellular marker for proliferation in cancer or premalignant lesion. The aim of this study is to investigate whether p53 and Ki-67 measurements in gastric tumors would be helpful in determining treatment strategy. Methods: Immunohistochemical staining using monoclonal antibodies to p53 and Ki-67 was performed on specimens from 29 gastric adenomas (GA) by endoscopic submucosal dissection (ESD) and 240 gastric cancers (GC) by ESD or gastrectomy. Tumor cells with nuclear p53 and Ki-67 protein expression were arbitrarily graded into four groups: < 10 % = negative, 10-30 % = 1+, 30-60 % = 2+, and > 60 % = 3+. Results: The mean tumor sizes in the GA and GC groups were 17.3 ± 11.4 mm and 32.0 ± 20.9 mm respectively (P < 0.001). p53 positivity was not different between the GA and GC groups (P = 0.149), but Ki-67 positivity was significantly different between the 2 groups (P = 0.001). In addition, Ki-67 positivity tended to be increased as the pathologic progression changed from adenoma to cancer. Conclusions: Ki-67 positivity grade seems to be correlated with malignancy potential. Even if endoscopic biopsy showed low grade dysplasia, in lesions with high Ki-67 positivity, it is better to consider active ESD rather than just long-term follow up. © Copyright Celsius Publishing House. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.title | A pilot multicenter study evaluating the expression of p53 and ki-67 in gastric tumors and their utility for guiding treatment strategy | - |
dc.type | Article | - |
dc.identifier.doi | 10.21614/sgo-22-4-318 | - |
dc.identifier.bibliographicCitation | Surgery, Gastroenterology and Oncology, v.22, no.4, pp 318 - 324 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85044062780 | - |
dc.citation.endPage | 324 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 318 | - |
dc.citation.title | Surgery, Gastroenterology and Oncology | - |
dc.citation.volume | 22 | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Gastric adenoma | - |
dc.subject.keywordAuthor | Gastric cancer | - |
dc.subject.keywordAuthor | Immunohistochemistry | - |
dc.subject.keywordAuthor | Ki-67 | - |
dc.subject.keywordAuthor | P53 | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.