A pilot multicenter study evaluating the expression of p53 and ki-67 in gastric tumors and their utility for guiding treatment strategy
- Authors
- Baek, I.H.; Kim, K.O.; Kim, J.W.; Min, K.W.
- Issue Date
- Dec-2017
- Keywords
- Gastric adenoma; Gastric cancer; Immunohistochemistry; Ki-67; P53
- Citation
- Surgery, Gastroenterology and Oncology, v.22, no.4, pp 318 - 324
- Pages
- 7
- Journal Title
- Surgery, Gastroenterology and Oncology
- Volume
- 22
- Number
- 4
- Start Page
- 318
- End Page
- 324
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/63949
- DOI
- 10.21614/sgo-22-4-318
- ISSN
- 0000-0000
- Abstract
- Background: p53 mutation is the most common genetic alteration in cancers and influences clinical progression. Ki-67 protein is a cellular marker for proliferation in cancer or premalignant lesion. The aim of this study is to investigate whether p53 and Ki-67 measurements in gastric tumors would be helpful in determining treatment strategy. Methods: Immunohistochemical staining using monoclonal antibodies to p53 and Ki-67 was performed on specimens from 29 gastric adenomas (GA) by endoscopic submucosal dissection (ESD) and 240 gastric cancers (GC) by ESD or gastrectomy. Tumor cells with nuclear p53 and Ki-67 protein expression were arbitrarily graded into four groups: < 10 % = negative, 10-30 % = 1+, 30-60 % = 2+, and > 60 % = 3+. Results: The mean tumor sizes in the GA and GC groups were 17.3 ± 11.4 mm and 32.0 ± 20.9 mm respectively (P < 0.001). p53 positivity was not different between the GA and GC groups (P = 0.149), but Ki-67 positivity was significantly different between the 2 groups (P = 0.001). In addition, Ki-67 positivity tended to be increased as the pathologic progression changed from adenoma to cancer. Conclusions: Ki-67 positivity grade seems to be correlated with malignancy potential. Even if endoscopic biopsy showed low grade dysplasia, in lesions with high Ki-67 positivity, it is better to consider active ESD rather than just long-term follow up. © Copyright Celsius Publishing House.
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