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Abiotic production of sugar phosphates and uridine ribonudeoside in aqueous microdropletsopen access

Authors
Nam, InhoLee, Jae KyooNam, Hong GilZare, Richard N.
Issue Date
Nov-2017
Publisher
NATL ACAD SCIENCES
Keywords
sugar phosphorylation; uracil ribosylation; microdroplet chemistry; prebiotic chemistry; origin of life
Citation
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.114, no.47, pp 12396 - 12400
Pages
5
Journal Title
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume
114
Number
47
Start Page
12396
End Page
12400
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/63952
DOI
10.1073/pnas.1714896114
ISSN
0027-8424
1091-6490
Abstract
Phosphorylation is an essential chemical reaction for life. This reaction generates fundamental cell components, including building blocks for RNA and DNA, phospholipids for cell walls, and adenosine triphosphate (ATP) for energy storage. However, phosphorylation reactions are thermodynamically unfavorable in solution. Consequently, a long-standing question in prebiotic chemistry is how abiotic phosphorylation occurs in biological compounds. We find that the phosphorylation of various sugars to form sugar-1-phosphates can proceed spontaneously in aqueous microdroplets containing a simple mixture of sugars and phosphoric acid. The yield for D-ribose-1-phosphate reached over 6% at room temperature, giving a Delta G value of -1.1 kcal/mol, much lower than the +5.4 kcal/mol for the reaction in bulk solution. The temperature dependence of the product yield for the phosphorylation in microdroplets revealed a negative enthalpy change (Delta H = -0.9 kcal/mol) and a negligible change of entropy (Delta S = 0.0007 kcal/mol.K). Thus, the spontaneous phosphorylation reaction in microdroplets occurred by overcoming the entropic hurdle of the reaction encountered in bulk solution. Moreover, uridine, a pyrimidine ribonucleoside, is generated in aqueous microdroplets containing D-ribose, phosphoric acid, and uracil, which suggests the possibility that microdroplets could serve as a prebiotic synthetic pathway for ribonucleosides.
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대학원 (지능형에너지산업융합학과)
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