Transitions to different patterns of interstitial lung disease in scleroderma with and without treatment
- Authors
- Kim, Hyun J.; Tashkin, Donald P.; Gjertson, David W.; Brown, Matthew S.; Kleerup, Eric; Chong, Semin; Belperio, John A.; Roth, Michael D.; Abtin, Fereidoun; Elashoff, Robert; Tseng, Chi-Hong; Khanna, Dinesh; Goldin, Jonathan G.
- Issue Date
- Jul-2016
- Publisher
- BMJ PUBLISHING GROUP
- Citation
- ANNALS OF THE RHEUMATIC DISEASES, v.75, no.7, pp 1367 - 1371
- Pages
- 5
- Journal Title
- ANNALS OF THE RHEUMATIC DISEASES
- Volume
- 75
- Number
- 7
- Start Page
- 1367
- End Page
- 1371
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/64209
- DOI
- 10.1136/annrheumdis-2015-208929
- ISSN
- 0003-4967
1468-2060
- Abstract
- Objectives The aim is to investigate whether the 12-month quantitative changes in high-resolution CT (HRCT) measures of interstitial lung disease (ILD) are different, and to understand how they change, in patients with scleroderma-related ILD who receive drug therapy versus placebo. Methods HRCT images were acquired at baseline and at 12 months in 83 participants in Scleroderma Lung Study I, a clinical trial comparing treatment with oral cyclophosphamide versus placebo. A computer-aided model was used to quantify the extent of fibrotic reticulation, ground glass and honeycomb patterns and quantitative ILD (QILD: sum of these patterns) in the whole lung and the lung zone (upper, middle or lower) of maximal disease involvement. Results Mean QILD score decreased by 3.9% in the cyclophosphamide group while increasing by 4.2% in the placebo group in the most severe zone (p=0.01) and decreased by 3.2% in the cyclophosphamide group while increasing by 2.2% in the placebo group in the whole lung (p=0.03). Transitional probabilities demonstrated greater changes from a fibrotic to either a ground glass or normal pattern in the cyclophosphamide group and the reverse in the placebo group. Conclusions Changes in quantitative HRCT measures of ILD provide a sensitive indication of disease progression and response to treatment.
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