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Human Amniotic Membrane Extracts have Anti-Inflammatory Effects on Damaged Human Corneal Epithelial Cells In Vitro

Authors
Lee, Han-NaBernardo, RaymundoHan, Gi-YeonKim, Gyu-YoungKim, Ji-SooJung, Won-YongKim, Keun-NamKim, Jae-ChanKim, Chan-Wha
Issue Date
Jul-2016
Publisher
JOURNAL HARD TISSUE BIOLOGY
Keywords
Human amniotic membrane extract (HAE); Human corneal epithelial cell (hCEC); Anti-inflammatory effect; Interleukin-6 (IL-6); Interleukin-8 (IL-8)
Citation
JOURNAL OF HARD TISSUE BIOLOGY, v.25, no.3, pp 282 - 287
Pages
6
Journal Title
JOURNAL OF HARD TISSUE BIOLOGY
Volume
25
Number
3
Start Page
282
End Page
287
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/64210
DOI
10.2485/jhtb.25.282
ISSN
1341-7649
1880-828X
Abstract
The human amniotic membrane has therapeutic potential for several diseases such as cardiac ischemia, liver fibrosis, and ocular surface disorders. In the treatment of ocular surface disorders, human amniotic membrane transplantation promotes epithelial wound healing and suppresses inflammation. The objective of this study was to determine whether human amniotic membrane extracts (HAE) help damaged corneal epithelial cells recover from an inflammatory response. Human corneal epithelial cells (hCEC) which were induced inflammation were treated with human amniotic membrane extracts, and then the levels of inflammatory cytokines were measured. Human amniotic membrane extracts had an anti-inflammatory effect on damaged human corneal epithelial cells. More importantly, homogenized human amniotic membrane extracts of less than 3 kDa had a greater capacity for reducing inflammation and secretion of interleukin-6 (IL-6) and interleukin-8 (IL-8). Thus, these results indicate that the use of human amniotic membrane extracts is a promising treatment for ocular surface disorders accompanied by inflammation.
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