Yin-Yang 1 and Yin-Yang 2 exert opposing effects on the promoter activity of interleukin 4
- Authors
- Lee, Sung Ho; Cho, Young-Chang; Jeong, Hyung Min; Kim, Kyung Hee; Choi, Hyun Jin; Lee, Kwang Youl; Kang, Bok Yun
- Issue Date
- Apr-2016
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- YY1; YY2; IL-4; Th2 cell; Constitutive factor
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.39, no.4, pp 547 - 554
- Pages
- 8
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 39
- Number
- 4
- Start Page
- 547
- End Page
- 554
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/64284
- DOI
- 10.1007/s12272-015-0622-7
- ISSN
- 0253-6269
1976-3786
- Abstract
- Interleukin (IL)-4 acts on T cells as a growth and activation factor, and promotes the differentiation of type 2 T helper cells. In T cells, expression of the gene encoding IL-4 is regulated by inducible or constitutive factors. Yin-Yang (YY)-1 is one of constitutive transcription factors binding to the IL-4 promoter. The recently identified YY2 protein is similar to YY1, with both sharing high levels of homology in their zinc finger motifs. However, the role of YY2 in T cells is unclear. YY1 and YY2 were constitutively expressed in EL4 T cells, and their expression was not dependent on stimulation. IL-4 promoter (-741/+56 fragment) activity was enhanced by YY1, but inhibited by YY2. The enhanced IL-4 promoter activity by YY1 was reduced by simultaneous expression of YY2. In addition, the DNA binding affinity of YY1 to the IL-4 promoter was adversely affected by YY2. Our results suggest that YY1 and YY2 exert opposing effects on the IL-4 promoter as they compete for the same DNA binding sites.
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