Role of autophagy-related protein expression in patients with rectal cancer treated with neoadjuvant chemoradiotherapy
DC Field | Value | Language |
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dc.contributor.author | Shim, Byoung Yong | - |
dc.contributor.author | Sun, Der Sheng | - |
dc.contributor.author | Won, Hye Sung | - |
dc.contributor.author | Lee, Myung Ah | - |
dc.contributor.author | Hong, Soon Uk | - |
dc.contributor.author | Jung, Ji-Han | - |
dc.contributor.author | Cho, Hyeon-Min | - |
dc.contributor.author | Ko, Yoon Ho | - |
dc.date.accessioned | 2023-03-08T17:53:06Z | - |
dc.date.available | 2023-03-08T17:53:06Z | - |
dc.date.issued | 2016-03 | - |
dc.identifier.issn | 1471-2407 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/64318 | - |
dc.description.abstract | Background: Autophagy, a cellular degradation process, has complex roles in tumourigenesis and resistance to cancer treatment in humans. The aim of this study was to explore the expression levels of autophagy-related proteins in patients with rectal cancer and evaluate their clinical role in the neoadjuvant chemoradiotherapy setting. Methods: All specimens evaluated were obtained from 101 patients with colorectal cancer who had undergone neoadjuvant chemoradiotherapy and curative surgery. The primary outcomes measured were the expression levels of two autophagy-related proteins (microtubule-associated protein 1 light chain 3 beta (LC3 beta) and beclin-1) by immunohistochemistry and their association with clinicopathological parameters and patient survival. Results: Among the 101 patients, the frequency of high expression of beclin-1 was 31.7 % (32/101) and that of LC3 beta was 46.5 % (47/101). A pathologic complete response was inversely associated with LC3 beta expression (P = 0.003) and alterations in the expression of autophagy-related proteins (P = 0.046). In the multivariate analysis, however, autophagy-related protein expression did not show prognostic significance for relapse-free survival or overall survival. Conclusions: High expression of autophagy-related proteins shows a strong negative association with the efficacy of neoadjuvant chemoradiotherapy in patients with rectal cancer. Autophagy has clear implications as a therapeutic target with which to improve the efficacy of neoadjuvant chemoradiotherapy. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.title | Role of autophagy-related protein expression in patients with rectal cancer treated with neoadjuvant chemoradiotherapy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s12885-016-2250-0 | - |
dc.identifier.bibliographicCitation | BMC CANCER, v.16, no.1 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000371672400005 | - |
dc.identifier.scopusid | 2-s2.0-84960391168 | - |
dc.citation.number | 1 | - |
dc.citation.title | BMC CANCER | - |
dc.citation.volume | 16 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Rectal cancer | - |
dc.subject.keywordAuthor | Neoadjuvant chemoradiotherapy | - |
dc.subject.keywordAuthor | Autophagy | - |
dc.subject.keywordAuthor | LC3 beta | - |
dc.subject.keywordAuthor | Beclin-1 | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR | - |
dc.subject.keywordPlus | COLON-CANCER | - |
dc.subject.keywordPlus | PREOPERATIVE RADIOTHERAPY | - |
dc.subject.keywordPlus | PROGNOSTIC-SIGNIFICANCE | - |
dc.subject.keywordPlus | BECLIN-1 | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | PATTERNS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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