Role of autophagy-related protein expression in patients with rectal cancer treated with neoadjuvant chemoradiotherapyopen access
- Authors
- Shim, Byoung Yong; Sun, Der Sheng; Won, Hye Sung; Lee, Myung Ah; Hong, Soon Uk; Jung, Ji-Han; Cho, Hyeon-Min; Ko, Yoon Ho
- Issue Date
- Mar-2016
- Publisher
- BIOMED CENTRAL LTD
- Keywords
- Rectal cancer; Neoadjuvant chemoradiotherapy; Autophagy; LC3 beta; Beclin-1; Prognosis
- Citation
- BMC CANCER, v.16, no.1
- Journal Title
- BMC CANCER
- Volume
- 16
- Number
- 1
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/64318
- DOI
- 10.1186/s12885-016-2250-0
- ISSN
- 1471-2407
- Abstract
- Background: Autophagy, a cellular degradation process, has complex roles in tumourigenesis and resistance to cancer treatment in humans. The aim of this study was to explore the expression levels of autophagy-related proteins in patients with rectal cancer and evaluate their clinical role in the neoadjuvant chemoradiotherapy setting. Methods: All specimens evaluated were obtained from 101 patients with colorectal cancer who had undergone neoadjuvant chemoradiotherapy and curative surgery. The primary outcomes measured were the expression levels of two autophagy-related proteins (microtubule-associated protein 1 light chain 3 beta (LC3 beta) and beclin-1) by immunohistochemistry and their association with clinicopathological parameters and patient survival. Results: Among the 101 patients, the frequency of high expression of beclin-1 was 31.7 % (32/101) and that of LC3 beta was 46.5 % (47/101). A pathologic complete response was inversely associated with LC3 beta expression (P = 0.003) and alterations in the expression of autophagy-related proteins (P = 0.046). In the multivariate analysis, however, autophagy-related protein expression did not show prognostic significance for relapse-free survival or overall survival. Conclusions: High expression of autophagy-related proteins shows a strong negative association with the efficacy of neoadjuvant chemoradiotherapy in patients with rectal cancer. Autophagy has clear implications as a therapeutic target with which to improve the efficacy of neoadjuvant chemoradiotherapy.
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