Interaction of EGFR to delta-catenin leads to delta-catenin phosphorylation and enhances EGFR signaling

Abstract

Expression of delta-catenin reportedly increases during late stage prostate cancer. Furthermore, it has been demonstrated that expression of EGFR is enhanced in hormone refractory prostate cancer. In this study, we investigated the possible correlation between EGFR and delta-catenin in prostate cancer cells. We found that EGFR interacted with delta-catenin and the interaction decreased in the presence of EGF. We also demonstrated that, on one hand, EGFR phosphorylated delta-catenin in a Src independent manner in the presence of EGF and on the other hand, delta-catenin enhanced protein stability of EGFR and strengthened the EGFR/Erk1/2 signaling pathway. Our findings added a new perspective to the interaction of EGFR to the E-cadherin complex. They also provided novel insights to the roles of delta-catenin in prostate cancer cells.