Weekly rituximab consolidation following four cycles of R-CHOP induction chemotherapy in very elderly patients with diffuse large B-cell lymphoma: Consortium for improving survival of lymphoma study (CISL)
- Authors
- Jung, Sung-Hoon; Lee, Je-Jung; Kim, Won Seog; Lee, Won-Sik; Do, Young Rok; Oh, Sung Yong; Kim, Min Kyoung; Mun, Yeung-Chul; Shin, Ho-Jin; Kwak, Jae-Yong; Kang, Hye Jin; Won, Jong Ho; Kwon, Jung Hye; Park, Eunkyung; Suh, Cheolwon; Yang, Deok-Hwan
- Issue Date
- Jun-2015
- Publisher
- WILEY
- Keywords
- elderly; diffuse large B-cell lymphoma; rituximab consolidation
- Citation
- EUROPEAN JOURNAL OF HAEMATOLOGY, v.94, no.6, pp 504 - 510
- Pages
- 7
- Journal Title
- EUROPEAN JOURNAL OF HAEMATOLOGY
- Volume
- 94
- Number
- 6
- Start Page
- 504
- End Page
- 510
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/64550
- DOI
- 10.1111/ejh.12459
- ISSN
- 0902-4441
1600-0609
- Abstract
- This study aimed to determine the objective response, toxicity, and clinical outcome of weekly rituximab consolidation after four cycles of R-CHOP21 in very elderly patients with DLBCL. A prospective, multi-institutional phase II trial was conducted on patients with previously untreated CD20(+) DLBCL who were older than 70yr. Patients were treated with four cycles of R-CHOP21 followed by weekly consolidation with rituximab (375mg/m(2), four times infusion) (NCT01181999). We also compared the clinical outcomes with an historical case-matched control group treated conventionally with six cycles of R-CHOP21. A total of 51 patients with newly diagnosed DLBCL were enrolled at 15 institutes between June 2010 and September 2013. The median age was 76yr (range: 70-89). Forty-one of the 51 patients completed the planned rituximab consolidation (R-consolidation). The overall response rate was 78.4%, comprising 74.5% with a complete response and 3.9% with a partial response. After a median follow-up of 20.3 months, 2-yr progression-free survival and overall survival were 63.9% and 68.7%, respectively. No serious toxicities were reported during rituximab consolidation. Weekly rituximab consolidation following four cycles of R-CHOP21 resulted in an acceptable response with high tolerability and could be a good compromise between efficacy and safety for elderly patients with DLBCL.
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