Artesunate inhibits proliferation of na < ve CD4(+) T cells but enhances function of effector T cells
DC Field | Value | Language |
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dc.contributor.author | Lee, Sung Ho | - |
dc.contributor.author | Cho, Young-Chang | - |
dc.contributor.author | Kim, Kyung Hee | - |
dc.contributor.author | Lee, Ik-Soo | - |
dc.contributor.author | Choi, Hyun Jin | - |
dc.contributor.author | Kang, Bok Yun | - |
dc.date.accessioned | 2023-03-08T18:59:48Z | - |
dc.date.available | 2023-03-08T18:59:48Z | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.issn | 1976-3786 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/64554 | - |
dc.description.abstract | Artesunate is an artemisinin derivative from Artemisia annua and is being applied as a first-line drug for malaria treatment. In addition to anti-malarial effects, anti-cancer, anti-viral, and anti-inflammatory activities have been reported for artemisinin derivatives. In this study, we investigated the effects of artesunate on na < ve T cell activation and Th1/Th2 differentiation. Artesunate inhibited the proliferation of CD4(+) T cells and the production of IL-2, T cell growth factor. Moreover, artesunate reduced the expression of cell surface protein CD25 (IL-2 receptor alpha chain) and CD69 on CD4(+) T cells. Artesunate showed inhibitory effects on na < ve T cell activation but artesunate increased the production of IFN-gamma and IL-4 under Th1 and Th2 skewed condition respectively. Therefore, these results suggest that artesunate has a negative mitogenic effect on CD4(+) T cells but reinforces the function of effector T cells. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PHARMACEUTICAL SOC KOREA | - |
dc.title | Artesunate inhibits proliferation of na < ve CD4(+) T cells but enhances function of effector T cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s12272-014-0491-5 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.38, no.6, pp 1195 - 1203 | - |
dc.identifier.kciid | ART001998137 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000355946600031 | - |
dc.identifier.scopusid | 2-s2.0-84930872251 | - |
dc.citation.endPage | 1203 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1195 | - |
dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.volume | 38 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Artesunate | - |
dc.subject.keywordAuthor | CD4(+) T cell | - |
dc.subject.keywordAuthor | Proliferation | - |
dc.subject.keywordAuthor | Differentiation | - |
dc.subject.keywordAuthor | Cytokine | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | ARTEMISININ DERIVATIVES | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | DIHYDROARTEMISININ | - |
dc.subject.keywordPlus | ENDOPEROXIDES | - |
dc.subject.keywordPlus | EXPRESSIONS | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | COMMITMENT | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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