Artesunate inhibits proliferation of na < ve CD4(+) T cells but enhances function of effector T cells
- Authors
- Lee, Sung Ho; Cho, Young-Chang; Kim, Kyung Hee; Lee, Ik-Soo; Choi, Hyun Jin; Kang, Bok Yun
- Issue Date
- Jun-2015
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- Artesunate; CD4(+) T cell; Proliferation; Differentiation; Cytokine
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.38, no.6, pp 1195 - 1203
- Pages
- 9
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 38
- Number
- 6
- Start Page
- 1195
- End Page
- 1203
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/64554
- DOI
- 10.1007/s12272-014-0491-5
- ISSN
- 0253-6269
1976-3786
- Abstract
- Artesunate is an artemisinin derivative from Artemisia annua and is being applied as a first-line drug for malaria treatment. In addition to anti-malarial effects, anti-cancer, anti-viral, and anti-inflammatory activities have been reported for artemisinin derivatives. In this study, we investigated the effects of artesunate on na < ve T cell activation and Th1/Th2 differentiation. Artesunate inhibited the proliferation of CD4(+) T cells and the production of IL-2, T cell growth factor. Moreover, artesunate reduced the expression of cell surface protein CD25 (IL-2 receptor alpha chain) and CD69 on CD4(+) T cells. Artesunate showed inhibitory effects on na < ve T cell activation but artesunate increased the production of IFN-gamma and IL-4 under Th1 and Th2 skewed condition respectively. Therefore, these results suggest that artesunate has a negative mitogenic effect on CD4(+) T cells but reinforces the function of effector T cells.
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